MSC 1094308( MSC1094308 )

Catalog No. M13537 CAS No. 2219320-08-6

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Product Name

MSC 1094308
Note

Research use only, not for human use.
Brief Description

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
Description

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively; binds to drugable hotspot of p97, thereby inhibiting the D2 ATPase activity; is active in cells, and specifically inhibits p97 but not the proteasome.
In Vitro

Western Blot Analysis Cell Line:HCT116 cells Concentration:10 μM Incubation Time:8 h Result:Led to accumulation of polyubiquitinated proteins (a biomarker for degradation inhibition).
In Vivo

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Synonyms

MSC1094308
Pathway

Proteasome/Ubiquitin
Target

p97
Recptor

p97
Research Area

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Indication

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CAS Number

2219320-08-6
Formula Weight

462.56
Molecular Formula

C29H29F3N2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (108.10 mM)
SMILES

FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1
Chemical Name

N-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine

1. P?hler R, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

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