MSC 1094308
CAS No. 2219320-08-6
MSC 1094308 ( MSC1094308 )
Catalog No. M13537 CAS No. 2219320-08-6
MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameMSC 1094308
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NoteResearch use only, not for human use.
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Brief DescriptionMSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
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DescriptionMSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively; binds to drugable hotspot of p97, thereby inhibiting the D2 ATPase activity; is active in cells, and specifically inhibits p97 but not the proteasome.
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SynonymsMSC1094308
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PathwayProteasome/Ubiquitin
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Targetp97
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Recptorp97
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Research Area——
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Indication——
Chemical Information
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CAS Number2219320-08-6
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Formula Weight462.56
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Molecular FormulaC29H29F3N2
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Purity>98% (HPLC)
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Solubility——
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SMILESFC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1
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Chemical NameN-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Phler R, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.
molnova catalog
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